Biochemistry and Molecular Biophysics E-Newsletter

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Tim Lohman-2015 Biophysical Society Fellow

2014 - BCM/MBCP Retreat

Crossing Paths in England

Welcome to New BMB Students & Postdocs

Research Awards

Latest Publications
2015 Biophysical Society Fellow

Timothy Lohman is being honored for his pioneering biophysical studies of the mechanisms and energetics of protein-DNA interactions, including the enzymology and kinetic mechanisms of DNA helicases and translocases, and single stranded DNA binding proteins. The awards ceremony will be held at the Biophysical Society’s 59th Annual Meeting in February 2015.
2014 BCM/CMBP Retreat
On October 17th and 18th, the Biochemistry and Computational & Molecular Biophysics Graduate program retreat was held at Cedar Creek Conference Center in New Haven, MO. In addition to various student speakers, the retreat featured two keynote speakers from our very own Washington University community. Dr. Jan Bieschke,  Assistant Professor in the Department of Biomedical Engineering and Dr. Timothy Wencewicz, Assistant Professor in the Department of Chemistry at Washington University.  Dr. Bieschke spoke on "Protein Misfolding  Mechanisms and Intervention"; while Dr. Wencewicz spoke on the  "New Antibiotics from Nature's Chemical Inventory". More photos...
Talk Winner:

Jayan Rammohan
Student Posters:
Josh Brettmann
John Robinson
(runner up)
Postdoc Posters:
Joshua Sokoloski
Saurabh Pratap Singh
(runner up)
BMB Department welcomes....
Amit Mandal-Postdoctoral Research Associate in Linda Pike's lab.
Robb Welty-Graduate Student in Kathleen Hall's lab.
Supun Wijayasinghe-Postdoctoral Research Associate in Tom Ellenberger's lab.
Yihu Yang-Postdoctoral Research Associate in Weikai Li's lab.
 Crossing Paths

Peter Burgers, Roberto Galletto, Eric Galburt and Tim Lohman were in Cambridge, England at the Eagle Pub where, in 1953, Watson and Crick famously announced their structure of DNA saying "We have discovered the secret of life".
Research Awards

Peter M. Burgers, Ph.D., Marvin A. Brennecke Professor of Biological Chemistry has received a four year renewal grant award from the NIGMS for his research entitled "Enzymology of Replication of Yeast Chromosomal DNA". He has also received along with Amir Aharoni, PhD, professor, Ben Gurion University, a new two year grant award from the U.S. – Israel Binational Science Foundation for his research entitled “Switching of DNA Polymerases on the PCNA Ring during DNA Damage Response”.

Carl Frieden, Ph.D., professor, received a new five year Grant Award from the National Institute on Aging for his research entitled “Alzheimer’s Disease: Defining the apoE-amyloid-beta interaction”.

Kathleen B. Hall, Ph.D., professor, received 
 a gift from Agilent Technologies, Inc. for her research entitled “RNA conformational probing by selective labeling using low field NMR”.

James Janetka, Ph.D., associate professor, along with Henry Han, PhD, assistant professor of neurological surgery, received a new one year grant award from the University Research Strategic Alliance program for their research entitled “Selective diagnostic imaging agents for cerebral amyloid angiopathy (CAA) plaques in Alzheimer’s disease”.

Weikai Li, Ph.D., assistant professor, received a new two year Grant in Aid Award from the American Heart Association for his research entitled “Mechanism of VKOR function and warfarin inhibition”.

Garland Marshall, Ph.D., professor, has received an equipment supplement grant award from the National Institute of General Medical Sciences for his research entitled “Discovery of New Therapeutics for Drug-Free Remission of HIV”.
Upcoming Events:

November 7, 2014
BMB Science Fridays
Andrew Meiburg  - Investigation by Key Residues in the MO Helix of NaK

Nicole Fazio - The Role of the C-terminal Linker of SSB in Diffusion on ssDNA

November 11,  2014
Biophysical Evenings
Tom Ellenberger - poly-(ADP-ribose) Metabolism and Cancer Therapeutics

November 13, 2014
BMB Special Seminar
R. Kip Guy - (+)-SJ733, a Clinical Candidate for Malaria Targeting PfATP4

November 14, 2014
BMB Science Fridays
Anne Georges - TBA

November 18, 2014
Cori Lecture 
Joan Steitz - Noncoding RNAs: With a Viral Twist

November 20, 2014
BMB Special Seminar
Gunda Georg - Drug Discovery in Academia: Minnelide for Pancreatic Cancer and Gamendazole for Male Contraception

November 21, 2014
BMB Science Fridays
Guest speaker from Greg Bowman - TBA

December 2, 2014
BMB Seminar
Matthew Bogyo - Using Small Molecules to Discover and Dissect Regulators of Pathogenesis

December 5, 2014
BMB Science Fridays
Michael Simon - TBA

December 9, 2014
BMB Seminar
Stephen C. Blacklow - Unraveling the Mechanism of Normal and Oncogenic Notch Signaling

December 10, 2014
BMB Seminar
David Millar - Visualizing Protein Function at the Single-molecule Level

December 12, 2014
BMB Science Fridays
Sarem Hailemariam - TBA

Lastest Publications

Dovrat, D., Stodola, J.L., Burgers, P.M. and Aharoni, A. Sequential Switching of Binding Partners on PCNA During in vitro Okazaki Fragment Maturation. PNAS 111:14118-14123 (2014)

Edwards, M. Zwolak, A., Schafer, D.A., Sept, D., Dominguez, R. and Cooper, J.A. Capping Protein Regulators Fine-tune Actin Assembly Dynamics. Nature Reviews Molecular Cell Biology 15:677-689 (2014).

Garai, K., Verghese, P.B., Baban, B., Holtzman, D.M. and Frieden, C. The Binding of apoE to Oligomers and Fibrils of Amyloid-beat Alters the Kinetics of Amyloid Aggregation. Biochemistry 53:6323-6331 (2014).

Nguyen, B., Sokoloski, J.E., Galletto, R.Elson, E.L., Wold, M.S. and Lohman, T.M. Diffusion of Human Replication Protein A Along Single Stranded DNA. J. Mol Biol 426:3246-3261 (2014)

Han, Z., Harris, P.K.W., Jones, D.E., Chugani, R., Kim, T., Agarwal, M., Shen, W., Wildman, S.A. and Janetka, J.W. Inhibitors of HGFA, Matriptase and Hepsin Serine Proteases: A Non-Kinase Strategy to Block Cell Signaling in Cancer. ACS Med. Chem. Lett. (E-pub ahead of print.) (2014).

Liu, C., Ponder, J.W. and Marshall, G.R. Helix Stability of Oligoglycine, Oligoalanine and Oligo-beta-alanine Dodecamers Reflected by Hydrogen-bond Persistence. Proteins (E-pub ahead of print.) (2014).


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